We are a research laboratory embedded in the campus of UT Southwestern in Dallas, Texas. Our goal is to tackle challenging problems in human health and cancer biology. We work on the diseases of triple-negative breast cancer and other difficult-to-treat cancers. We are especially interested in how these cancers interface with metabolic processes and host immunity. Our science is focused on how chromatin is made in dividing cells and how the epigenome is controlled. This has led us towards enzymes and cell surface receptors that control mammalian biosynthetic processes as cancer targets. We have a long-term goal of identifying new targets for drug development, establishing therapeutic principles and translating them to humans.

The interface of technology & health

We are particularly interested in engineering and design of cells, enzymatic reactions, and chemicals to solve problems and serve as model systems for biology and disease. We are dedicated to developing methodologies, technologies and reagents for ourselves and the scientific community at large. We seek to re-design the genome, the epigenome and immunome to derive insights about how biological systems are controlled and how they go haywire in disease.